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Current intelligence bulletin 19 - 2,4-diaminoanisole (4-methoxy-m-phenylediamine) in hair and fur dyes.
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-111 (CIB 19), 1978 Jan; :1-7
NIOSH recommends that 2,4-diaminoanisole (615054), or 4-methoxy-m- phenylenediamine, and its salts be handled in the work place as if they were human carcinogens. This recommendation is based primarily upon a preliminary analysis of the National Cancer Institute data indicating that rats fed 2,4-diaminoanisole experience statistically significant excess of site specific malignant tumors as compared to controls. Caution is also indicated by NIOSH epidemiologic studies which suggest an elevated incidence of cancer among cosmetologists. Exposures should be limited to as few employees as possible, while minimizing workplace exposure levels with engineering and work practice controls. In particular, skin exposures should be avoided.
NIOSH-Author; NIOSH-Current-Intelligence-Bulletin-No-19; Carcinogens; Oxidizers; Industrial-hygiene; Epidemiology; Cosmetics-workers; Chemical-industry-workers; Animal-products-workers; Amines; Toxicology; Hairdressers; Occupational-diseases; Safety-measures; Control-methods
Numbered Publication; Current Intelligence Bulletin
NTIS Accession No.
DHEW (NIOSH) Publication No. 78-111; CIB 19
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division