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Methyl Chloride Occupational Hazards.
NIOSH 1977 Oct:29-36
This information profile on methyl-chloride (74873) lists its chemical structure, Chemical Abstracts Service number, Registry of Toxic Effects of Chemical Substances number, production figures and economic trends in production, uses, number of companies producing and using the substance, and the biological effects of exposure. The toxic effects of methyl-chloride are believed to result from the methylation of essential enzymes, cofactors, and proteins, thereby rendering them inactive. Acute effects, subchronic effects, and chronic effects are discussed. In mild cases of human poisoning the symptoms include nausea, vomiting, colicky pains and diarrhea. Vertigo, general weakness, blurred vision, drowsiness, and muscle incoordination are also reported. Poisoning also results in hepatic and renal damage along with congestion of the lungs, petechial hemorrhages of pleura, epicardium, and endocardium. The threshold limit value for exposure to methyl-chloride has been set at 100ppm, which is the level recommended by OSHA. (Contract No. 210-77-0120)
NIOSH-Contract; Contract-210-77-0120; Toxic-substances; Anesthetics; Explosives; Chlorinated-hydrocarbons; Refrigerants; Chloromethanes; Thresholds; Neuromotor-disorders; Gastrointestinal-system-disorders; Nervous-system-disorders; Eye-disorders; Liver-disorders; Kidney-disorders;
Information Profiles on Potential Occupational Hazards, NIOSH Contract No. 210-77-0120, October 1977
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division