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Toxic Evaluation of Inhaled Chlorobenzene (Monochlorobenzene).
NIOSH 1977 Jun:77 pages
Male rats and rabbits were exposed to 0, 75, or 250ppm chlorobenzene (108907) vapors for 7 hours daily, 5 days per week, for up to 120 exposure days (24 weeks). Groups of animals from both species were sacrificed after 5 and 11 weeks of treatment and examined for hematology, clinical chemistry, and gross and histopathological changes resulting from the chlorobenzene treatment. A statistical analysis of the data suggests some treatment-related effect on the red cell parameters. There appeared to be a small effect on food utilization in rats. Pathological changes were mostly found in rats, where occasional focal lesions in the adrenal cortex, tubular lesions in the kidneys, and congestion in the liver and kidneys suggested a treatment relationship. The subtle changes observed in rats at 75 and 250ppm suggest that the current maximum permissible concentration for chlorobenzene of 75ppm may be too high and that 5 to 10ppm may be a better working level. (Contract No. 210-76-0126)
NIOSH-Contract; Contract-210-76-0126; Chlorinated-benzenes; Kidney-disorders; Toxicology; Liver-disorders; Exposure-limits; Endocrine-system-disorders; Organic-solvents; Genetics; Histopathology; Hepatotoxicity; Nephrotoxicity;
NTIS Accession No.
Division of Biomedical and Behavioral Sciences, NIOSH
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division