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Ocular ultraviolet effects from 295 nm to 400 nm in the rabbit eye.
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 77-175, 1977 Oct; :1-88
Pigmented rabbit eyes were irradiated with ultraviolet in 5 nanometer intervals from 290 to 320 nanometers and in 10 nanometer intervals from 325 to 400 nanometers. Ocular tissues were studied with the electron microscope to localize and describe the morphology of the damage. The upper limit of the action spectrum for cornea was established at 320 nanometers. The most efficient waveband for lenticular damage was 300 nanometers which gave a radiant exposure threshold of 0.15 joules per square centimeter. The lenticular radiant exposure threshold produced lenticular opacities which disappeared within 24 hours to 2 weeks. Permanent cataracts occurred at radiant exposure levels approximately twice the threshold exposure. Radiant exposures of twice the threshold exposure for the cornea resulted in irreversible corneal damage in the form of stromal haze, stromal opacities, endothelial changes, and anterior uveitis. Preliminary studies on a primate at 300 nanometers gave a corneal threshold and a lens threshold of 0.01 and 74-0012)
NIOSH-Contract; Contract-099-74-0012; Ultraviolet-radiation; Electromagentic-radiation; Eye-disorders; Vision-disorders; Cornea-disorders; Histopathology
NTIS Accession No.
DHEW (NIOSH) Publication No. 77-175; Contract-099-74-0012
National Institute for Occupational Safety and Health
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division