Asbestos contamination of parenteral drugs.
Nicholson-WJ; Maggiore-CJ; Selikoff-IJ
Science 1972 Jul; 177(4044):171-173
Fibrous particulates are determined in samples of parenteral drugs obtained during 1969, 1970, and 1971, by optical microscope or electron microscope. The optical determinations are made on one quarter of each sample and the electron-microcope determinations are made on .00001 part of each sample. All 20 drugs analyzed are labeled for intravenous use except three for intramuscular and one for intraperitoneal use. Some fibers in the samples are identified as chrysotile by optical microscopy, while many fibers are asbestos. Although the drug samples represent only a small fraction of those on the market, the results of the analysis should cause concern since finding asbestos fibers in one third of the single vials examined over a year's time indicates significant asbestos contamination.
NIOSH-Publication; NIOSH-Grant; Analytical-methods; Foreign-bodies; Contamination; Pollution; Pharmaceuticals; Contaminants; Particulates
Community Medicine MT Sinai School of Medicine Fifth Avenue and 100 Street New York, N Y 10029
Mount Sinai School of Medicine, New York, New York