Chromosomal damage in men occupationally exposed to vinyl chloride monomer and other chemicals.
Heath-CW Jr.; Dumont-CR; Gamble-J; Waxweiler-RJ
Environ Res 1977 Aug; 14(1):68-72
Chromosome breakage was determined in 14 polyvinyl-chloride (9002862) (PVC) polymerization workers (presumed high exposure to vinyl-chloride (75014) monomer), 4 workers in PVC processing (presumed low exposure), 17 in rubber tire manufacturing (presumed negligible exposure) and in 4 employees at the Center for Disease Control not exposed directly to any laboratory chemicals, as part of a larger study designed to provide multiphasic medical screening data on men employed at a large rubber and plastics plant. Men in all three industrial categories had been employed 10 years or longer. No significant differences were found between the three worker groups, but breakage levels in all three groups were significantly increased over levels in the nonindustrial controls. Chromatid gaps comprised the majority (86 percent) of aberrations. That there were no significant differences in chromosome breakage between the three industrial categories with differences in exposure is considered to imply the presence of agents other than vinyl- chloride monomer capable of inducing chromosome breaks.
NIOSH-Author; Chromosome-damage; Genetic-disorders; Hazards; Chemical-industry-workers; Rubber-manufacturing-industry; Plastics-manufacturing; Chemical-industry; Carcinogens; Chlorinated-hydrocarbons; Mutagenicity; Mutagens