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A cross-sectional epidemiologic survey of vinyl chloride workers.
Waxweiler-RJ; Falk-H; McMichael-A; Mallov-JS; Grivas-AS; Stringer-WT
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 77-177, 1977 Jun; :1-50
The extent to which vinyl chloride monomer induces clinical detectable abnormalities among workers occupationally exposed was investigated during a cross-sectional medical survey at a chemical plant which had a polyvinylchloride polymerization operation, a polyvinyl chloride fabrication operation, and a rubber tire production operation. The survey of 433 predominantly white male employees, divided into four vinyl chloride exposure groups (never, light, heavy, former), determined the prevalence of illnesses and abnormalities based on data gathered by interview, medical examination, blood and pulmonary function tests, liver scans, and hand and chest X-rays. Age-adjusted analyses indicated that hepatomegaly, central nervous system symptoms, diastolic hypertension and spouses' fetal wastage (the latter two statistically significant) were more prevalent among past or present vinyl chloride exposed workers than among controls. Although vinyl chloride related respiratory system problems, acroosteolysis, Raynaud's phenomenon, and chromosome aberrations have been identified by other investigators, no excessive prevalence of these toxic effects was found in this population compared with industrial worker controls.
NIOSH-Author; Vinyl-monomers; Chlorinated-ethylenes; Plastics-industry; Statistical-analysis; Chemical-processing-industry; Vinyl-plastics; Liver-disorders; PM9002862; Nervous-system-disorders; Circulatory-system-disorders; Reproduction-system-disorders; Epidemiology
NTIS Accession No.
DHEW (NIOSH) Publication No. 77-177
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division