Ventilatory functions in germfree and conventional rats exposed to coal dusts.
Moorman-WJ; Hornung-RW; Wagner-WD
Proc Soc Exp Biol Med 1977 Jul; 155(3):424-428
Ventilatory functions were studied in conventional and germfree rats exposed to 10 milligrams per cubic meter of bituminous coal dust for 120 days. The pulmonary function parameters included: inspiratory capacity, vital capacity, forced expiratory volumes in 0.5 and 1.0 second, peak expiratory flow rate, and flow maximas at 25 and 10 percent of the vital capacity. The coal exposed rats, both conventional and germfree, exhibited significantly lower responses for the flow maxima at 10 percent of the vital capacity when compared with the corresponding control groups. However, such differences in germfree rats were more clearly distinguishable because of the small intragroup variability. This work presents evidence that airway obstruction occurs in rats as a result of a coal dust exposure alone.
NIOSH-Author; Respiratory-functions; Dust-inhalation; Respiratory-system-disorders; Rodents; Statistical-analysis; Particulate-dust; Respirable-dust; Microorganisms
Proceedings of the Society for Experimental Biology and Medicine