Binding of bismuth in the kidneys of the rate: The role of metallothionein-like proteins.
Szymanska-JA; Mogilnicka-EM; Kaszper-BW
Biochem Pharmacol 1977 Feb; 26(3):257-258
Experiments were carried out in female rats injected subcutaneously with bismuth (7440699), in the form of radioactive labeled bismuth- chloride (7787602), in order to determine whether the level of metallothionein like proteins is elevated by repeated administration of the metal. According to the results obtained it follows that the elevated capacity of kidneys for bismuth, observed when the metal is administered repeatedly, is connected with metallothionein like proteins the level of which is enhanced by this element. Whether these proteins are identical with those which aid the storage of mercury in the kidneys requires further studies.
NIOSH-Publication; NIOSH-Grant; Protein-binding; Metal-poisoning; Heavy-metals; Biochemistry; Metalloproteins; Toxicology; Nephrotoxicity