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The neuropathology of industrial neuropathies.

Authors
Spencer PS; Schaumburg HH
Source
International Symposium on Neurotoxicology, May 16-19 1976. 1976 May; :1-9
Link
NIOSHTIC No.
00071487
Abstract
Acrylamide (79061) (10 milligrams per kilogram per day) and four chemically and biologically related straight chain hexacarbons, n- hexane (110543) (500ppm), methyl-n-butyl-ketone (300 milligrams per kilogram per day, subcutaneously), 2,5-hexanedione (110134) and 2,5- hexanediol (2935446) (as 0.5 percent drinking solutions) were used to study the pattern and spatial-temporal distribution of nervous system degeneration in the cat and rat. The results of the studies showed that all compounds produced a typical peripheral neuropathy which is characterized clinically by slowly-developing hindlimb weakness. Unlike the clinical expression of the disease, pathological changes are not confined to the peripheral nervous system, but occur concurrently in both the central and peripheral nervous system as axonal degeneration of the dying back type. It is suggested that the favored hypothesis to account for the dying-back process, progressive impairment of neuronal perikaryal metabolism, is not likely to be entirely responsible for distal axonal degeneration. (Grant No. R01-OH-00535)
Keywords
NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Neurotoxicity; Toxic-substances; Amides; Organic-solvents; Ketones; Solvents
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CAS No.
79-06-1; 110-54-3; 110-13-4; 2935-44-6
Publication Date
19760501
Document Type
Conference/Symposia Proceedings
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
International Symposium on Neurotoxicology, May 16-19 1976
State
NY
Performing Organization
Yeshiva University, New York, New York
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