Gastrointestinal motor inhibition associated with acute exposure to methyl methacrylate vapor.
Tansy-MF; Martin-JS; Benhaim-S; Landin-WE; Kendall-FM
J Pharm Sci 1976 Jan; :1-29
A mixture of monomeric methyl-methacrylate (80626) vapor in air was delivered into the breathing air of chloralose-urethan anesthetized dogs. Fixed length exposure to 2000ppm doses of the vapor resulted in a transient drop in arterial blood pressure and a marked inhibition of ongoing gastrointestinal motor activities. Motor inhibition always continued for a variable amount of time (on the order of 10 to 15 minutes) subsequent to the cessation of methyl- methacrylate vapor administration. This inhibitory response was not blocked by bilateral vagotomy, spinal transection, or splanchnectomy. It was not blocked by the intravenous administration of tetraethylammonium-chloride (56348). In another series of experiments it was determined that the administration of blood from a dog that was receiving methyl-methacrylate vapor would produce gastrointestinal motor inhibition in another dog that was not connected to the experimental gas mixture. It is therefore concluded that, aside from any reflex effects which might be produced, methyl-methacrylate vapor in sufficient concentration probably exerts a direct inhibitory effect upon gastrointestinal smooth muscle that is mediated by the cardiopulmonary systems. (Grant No. R01-OH-00518)
NIOSH-Grant; Pulmonary-system-disorders; Toxic-substances; Anesthetics; Breathing-atmospheres; Acrylates; Gastrointestinal-system; Physiological-response; Muscle-function
Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
Journal of Pharmaceutical Sciences
Temple University, Philadelphia, Pennsylvania