The importance of chronic testing of potentially neurotoxic compounds in experimental animals is emphasized to describe the range of hexacarbon compounds identified as neurotoxic agents, and to characterize and illustrate the pathological basis for the onset of the nervous system disease. The compounds tested are: n-hexane (110543), methyl-n-butylketone (591786), 2,5-hexanedione (110134), 2,5-hexanediol (2935446), 2,4-hexanedione, 2,3-hexanedione (3848246), and 1,6-hexanediol. Results show that animals chronically intoxicated with these neurotoxic hexacarbons slowly develop a peripheral neuropathy and display concurrent distal nerve fiber degeneration in the peripheral nervous system, and in ascending and descending spinal cord tracts of the central nervous system.
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