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Neurotoxic properties of certain aliphatic hexacarbons.
Spencer PS; Schaumburg HH
Proc R Soc Med 1977 Jan; 70(1):37-39
The importance of chronic testing of potentially neurotoxic compounds in experimental animals is emphasized to describe the range of hexacarbon compounds identified as neurotoxic agents, and to characterize and illustrate the pathological basis for the onset of the nervous system disease. The compounds tested are: n-hexane (110543), methyl-n-butylketone (591786), 2,5-hexanedione (110134), 2,5-hexanediol (2935446), 2,4-hexanedione, 2,3-hexanedione (3848246), and 1,6-hexanediol. Results show that animals chronically intoxicated with these neurotoxic hexacarbons slowly develop a peripheral neuropathy and display concurrent distal nerve fiber degeneration in the peripheral nervous system, and in ascending and descending spinal cord tracts of the central nervous system.
NIOSH-Publication; NIOSH-Grant; Grants-other; Neurotoxicity; Nervous-system-disorders; Chronic-toxicity; Organic-solvents; Aliphatic-hydrocarbons
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
110-54-3; 591-78-6; 110-13-4; 2935-44-6; 3848-24-6
Issue of Publication
Other Occupational Concerns; Grants-other
Proceedings of the Royal Society of Medicine
Yeshiva University, New York, New York
Page last reviewed: December 4, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division