Criteria for a recommended standard... occupational exposure to alkanes (C5-C8).
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 77-151, 1977 Mar; :1-137
This report presents the criteria and the recommended standard based thereon which were prepared to meet the need for preventing occupational disease and injury arising from workplace exposure to pentane (109660), hexane (110543), heptane (142825), or octane (111659). The standard is based on the conclusion that acute intoxication by these alkanes involves a transient central nervous system depression and the chronic intoxication may involve a more persistent effect, polyneuropathy. Polyneuropathy has usually been attributed to n-hexane, but exposures to n-hexane alone have not been described. Studies concerning animal toxicity are discussed. Evidence indicates that alkane concentrations needed to produce a physiological response decrease as the number of carbon atoms in the compound increase. However, no data have been reported on health effects from dermal exposure in the workplace and, other than the development of neuropathy, no correlation of environmental concentrations with observed toxic effects has been found.
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