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Investigation of alveolar macrophages from rats exposed to coal dust.
Bingham-E; Barkley-W; Murthy-R; Vassalo-C
Cincinnati, OH: University of Cincinnati, College of Medicine, Department of Environmental Health, Fourth International Symposium on Inhaled Particles and Vapors, Edinburgh, 22nd to 26th September, 1975, Grant No. R01-OH-00357, 1975 Jan; :1-14
Rats were exposed to the inhalation of coal dust from either Utah (low prevalence coal workers' pneumoconiosis (cwp)) or Pennsylvania (high prevalence cwp). Rats were number of alveolar macrophages recovered from rats inhaling these two coal dusts (exposures up to four months) was not remarkably different from the number recovered from rats inhaling filtered room air. This is in contrast to results obtained after intratracheal intubation of the dust. The capacity of the lavaged cells to phagocytize and kill bacteria decreased after exposure to either dust. The activity of certain enzymes also decreased.
NIOSH-Grant; Pulmonary-system-disorders; Dust-inhalation; Biological-indicators; Respiratory-system-disorders; Lung-disorders; Enzyme-activity; Host-resistance; Biochemical-responses; Biological-responses; Administration; Immunology
Environmental Health University of Cincinnati Eden and Bethesda Avenues Cincinnati, Ohio 45219
Investigation of alveolar macrophages from rats exposed to coal dust
PA; UT; OH
University of Cincinnati, Cincinnati, Ohio
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division