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Investigation of alveolar macrophages from rats exposed to coal dust.

Authors
Bingham-E; Barkley-W; Murthy-R; Vassalo-C
Source
Cincinnati, OH: University of Cincinnati, College of Medicine, Department of Environmental Health, Fourth International Symposium on Inhaled Particles and Vapors, Edinburgh, 22nd to 26th September, 1975, Grant No. R01-OH-00357, 1975 Jan; :1-14
Link
NIOSHTIC No.
00071243
Abstract
Rats were exposed to the inhalation of coal dust from either Utah (low prevalence coal workers' pneumoconiosis (cwp)) or Pennsylvania (high prevalence cwp). Rats were number of alveolar macrophages recovered from rats inhaling these two coal dusts (exposures up to four months) was not remarkably different from the number recovered from rats inhaling filtered room air. This is in contrast to results obtained after intratracheal intubation of the dust. The capacity of the lavaged cells to phagocytize and kill bacteria decreased after exposure to either dust. The activity of certain enzymes also decreased.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Dust-inhalation; Biological-indicators; Respiratory-system-disorders; Lung-disorders; Enzyme-activity; Host-resistance; Biochemical-responses; Biological-responses; Administration; Immunology
Contact
Environmental Health University of Cincinnati Eden and Bethesda Avenues Cincinnati, Ohio 45219
Publication Date
19750101
Document Type
Conference/Symposia Proceedings
Funding Amount
158962
Funding Type
Grant
Fiscal Year
1975
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00357
Source Name
Investigation of alveolar macrophages from rats exposed to coal dust
State
PA; UT; OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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