The chromosomal effects of chemicals in man may be studied by in- vivo or in-vitro methods. In vivo testing detects damage which has already occurred, while in vitro testing can be used to screen suspect chemicals and determine cytotoxicity levels. Chemicals which are known to cause chromosome damage include drugs, alkylating agents, solvents, inorganic chemicals, pesticides, food additives, and air and water pollutants. Exposure to these substances may result from use or occupational or environmental exposure. The medical implications of this damage are not known, and there are likely to be changes which are invisible and must be detected by other means. There is a great range in susceptibility to chromosome damage among individuals. (Grant No. R01-OH-00339)
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