GI motor inhibition associated with acute exposure to methyl methacrylate vapor.
Tansy MF; Martin JS; Benhaim S; Landin WE; Kendall FM
J Pharm Sci 1977 May; 66(5):613-618
A mixture of monomeric methyl-methacrylate (80626) vapor in air was delivered into the breathing air of anesthetized dogs. Fixed length exposures to 2000ppm doses of the vapor resulted in a transient drop in arterial blood pressure and a marked inhibition of ongoing gastrointestinal (GI) motor activities. Motor inhibition always continued for a variable time (10-15 minutes) subsequent to the cessation of methyl methacrylate vapor administration. This inhibitory response was not blocked by bilateral vagotomy, spinal transection, splanchnicectomy, or the intravenous administration of tetraethylammonium-chloride (56348). Another series of experiments determined that the administration of blood from a dog receiving methyl-methacrylate vapor produced GI motor inhibition in another dog not connected to the experimental gas mixture. Therefore, it is concluded that, aside from any reflex effects produced, methyl- methacrylate vapor in sufficient concentration probably exerts a direct inhibitory effect upon GI smooth muscle that is mediated by the cardiopulmonary systems.
NIOSH-Publication; NIOSH-Grant; Grants-other; Cardiovascular-system-disorders; Gastrointestinal-system-disorders; Pharmacology; Muscular-disorders; Nervous-system-function; Acrylates
Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
Journal of Pharmaceutical Sciences
Temple University, Philadelphia, Pennsylvania