The neurology and neuropathology of the occupational neuropathies.
Schaumburg HH; Spencer PS
J Occup Med 1976 Nov; 18(11):739-742
The relevant basic anatomy and pathology of peripheral nerve are reviewed and correlated with the clinico-pathological phenomena observed in some occupational neuropathies. The majority of occupational neuropathies are caused by neurotoxins in the work area and the clinico-pathological profiles indicate that they conform to the axonal type. Occupational neuropathies occurring subsequent to exposure to n-hexane (110543), acrylamide (79061), methyl-n-butyl- ketone, (591786) and 2,5-hexanedione (110134) are discussed in some detail. The most prominent feature in the clinical neurology of the hexacarbon neuropathies is the insidious onset of the progressive distal weakness and sensory loss in the lower extremities. Also mentioned are neuropathies induced by carbon-disulfide (75150) and o- cresyl-phosphate (78308).
JOCMA7; NIOSH-Publication; NIOSH-Grant; Grants-other; Nervous-system-disorders; Occupational-exposure; Industrial-chemicals; Organic-solvents; Toxicology; Pathology
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
110-54-3; 79-06-1; 591-78-6; 110-13-4; 75-15-0; 78-30-8
Journal of Occupational Medicine
Yeshiva University, New York, New York