Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds.
Chmielnicka-J; Balcerska-I; Pietruszczak-A; Brzeznicka-E
Bull Environ Contam Toxicol 1977 Apr; 17(4):447-455
In the course of 14 weeks exposure to mercury (7439976) compounds, including MetHg (a fluid seed dressing), mercuric-chloride (7487947), ethyl mercuric-chloride (107277) and phenyl-mercuric- chloride (100561), in doses corresponding to 5 percent of the median lethal dose three times a week, enhanced levels of activity of malate-dehydrogenase and glucose-phosphate isomerase in blood serum were observed. After 7 weeks of exposure about a four fold increase of malate-dehydrogenase (9001643) and two to three fold enhancement of glucose-phosphate isomerase activities were found relative to controls. After 14 weeks of exposure to MetHg or ethyl mercuric- chloride, organic mercury was found in the liver at concentrations of 28.8 and 4 micrograms per gram of tissue, respectively. Inorganic mercury was found in the livers of animals given any of the compounds.
NIOSH-Publication; NIOSH-Grant; Grants-other; Enzyme-activity; Organo-mercury-compounds; Toxic-substances; Blood-chemistry
7439-97-6; 7487-94-7; 107-27-7; 100-56-1; 9001-64-3
Other Occupational Concerns; Grants-other
Bulletin of Environmental Contamination and Toxicology