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HHE determination report no. HHE-76-36-369, supplemental report, (follow up medical study to HHE- 76-36-339) Eagle Picher Industries, Inc., Joplin, Missouri.
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HHE 76-36-369, 1977 Mar; :1-10
Results are presented of outpatient diagnostic studies performed by a board-certified nephrologist in 19 of 53 affected workers in whom an earlier NIOSH Health Hazard Evaluation, No. 76-036-0339, of lead (7439921) exposure at the Eagle Picher Industries, Lead Chemicals Plant (SIC-2819) in Joplin, Missouri established the presence of high blood urea nitrogen levels. Physical examinations were generally within normal limits, but the results of kidney function tests, blood lead levels, erythrocyte protoporphyrin, urinary delta- aminolevulinic-acid (106605) levels, the presence of anemia and high urinary beta-2-microglobulin levels in 7 of the workers tested demonstrated a significantly increased prevalence of moderately severe kidney disease in employees at the Eagle Picher plant in Joplin, Missouri. All workers had a history of heavy lead exposure for 5-30 years. A positive relationship was established between the degree of renal dysfunction and duration of lead exposure. Periodic screening of other lead exposed workers is indicated to detect early lead related renal disease, which could best be accomplished by measuring creatinine clearance and urinary concentrating ability every six months.
NIOSH-Author; HHE-76-36-369; NIOSH-Health-Hazard-Evaluation; Hazard-Unconfirmed; Region-7; Metal-poisoning; Lead-poisoning; Heavy-metals; Kidney-disorders; Blood-disorders; Blood-chemistry; Toxicology; Urine-chemistry; Diagnostic-tests; Clinical-tests; Preventive-medicine; Biochemistry; Author Keywords: HHE-76-36-339; Lead; Blood Lead; Lead Intoxication; Lead Toxicity; Anemia; Peripheral Neuropathy; Kidney Disease
Field Studies; Health Hazard Evaluation
NTIS Accession No.
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division