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Behavioral and neurological effects of methyl chloride.
Repko JD; Jones PD; Garcia LS Jr.; Schneider EJ; Roseman E; Corum CR
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 77-125, 1976 Dec; :1-215
Behavioral and neurological effects on workers exposed to methyl- chloride were evaluated. Seventy three behavioral measures of task performance, four indices of exposure to methyl-chloride, eight indicators of neurological function, a clinical electroencephalogram and demographic data were obtained from 122 workers occupationally exposed to methyl-chloride (74873) at 6 manufacturing plants using the solvent in fabricating processes. The duration of exposure correlated with airborne methyl-chloride, with methyl-chloride on the breath, and with blood hematocrit. Methyl-chloride on the breath also related to airborne methyl-chloride levels, while airborne methyl-chloride and urine acidity correlated with hematocrit. Methyl-chloride levels in ambient air and urine acidity were the two best indicators of workers' performance on behavioral tasks. No significant differences in the presence of abnormal neurological symptoms were noted between experimental and control groups. No significant differences were noted between exposed and non exposed groups with respect to the presence of dysrhythmia. Methyl-chloride adversely affected performance on cognitive time sharing tasks and increased finger tremor. No relation was noted between exposure and psychological or personality tests. (Contract No. 099-74-0020)
NIOSH-Contract; Contract-099-74-0020; Chlorinated-hydrocarbons; Urinalysis; Organic-solvents; Physiological-factors; Neurological-disorders; Nervous-system-disorders; Mental-processes; Behavior; Brain-disorders; Blood-chemistry; Cardiovascular-system-disorders; Psychological-factors
NTIS Accession No.
DHEW (NIOSH) Publication No. 77-125; Contract-099-74-0020
National Institute for Occupational Safety and Health
Page last reviewed: January 28, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division