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Behavioral and neurological effects of carbon disulfide.
Tuttle-TC; Wood-GD; Grether-CB
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 77-128, 1976 Dec; :1-166
The purpose of this investigation was to develop and apply a behavioral/neurological battery of tests to a sample of workers occupationally exposed to carbon-disulfide (75150). The neurological component of the investigation consisted of electro- diagnostic examinations of electromyograms, nerve conduction velocities, and a medical evaluation by a neurologist. Workers were also given psychometric tests of reaction time, coordination, visual search, short-term memory, and visual acuity. One hundred workers engaged in the manufacture of viscose rayon constituted the carbon- disulfide exposed group. Fifty workers engaged in similar work, but not occupationally exposed to carbon-disulfide, served as a control group. Since ambient air levels of carbon-disulfide could not be obtained within the viscose rayon plant, estimates of workers' exposure to carbon-disulfide were based on 1) detailed work history interviews with participants and 2) results from an iodine azide test for urine metabolites of carbon-disulfide. Based upon application of Allen's procedure of using a total neurologic score for assessment of peripheral neuropathy, 13 percent of the carbon- disulfide exposed workers showed a probable or definite polyneuropathy. After correcting for age effects, neurologic indicators or ulnar nerve damage was found to significantly correlate with indices of carbon-disulfide exposure, as did behavioral tests of reaction time dexterity, rate of visual search, and perceptual organization. (Contract No. 099-73-0035)
NIOSH-Contract; Contract-099-73-0035; Physiological-factors; Behavior; Urine-tests; Urinalysis; Neurological-disorders; Nervous-system-disorders; Metabolism; Perceptual-disorders; Mental-disorders; Mental-processes; Brain-disorders; Psychomotor-function; Perceptual-distortion; Sensory-perceptual-disorders
NTIS Accession No.
DHEW (NIOSH) Publication No. 77-128; Contract-099-73-0035
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division