Trace Metals in Human as a Simple Epidemiologic Monitor of Environmental Exposure.
Hammer-DI; Finklea-JF; Hendricks-RH; Hinners-TA; Riggan-WB; Shy-CM
Trace Substance in Environmental Health - V, A Symposium, D. D. Hemphill, Ed., University of Missouri, Columbia, Missouri 1972:25-38
Scalp hair metal levels were previously shown to reflect environmental exposure gradients for arsenic (7440382) (As), cadmium (7440439) (Cd) and lead (7439921) (Pb) in nonoccupationally exposed schoolboys. Four problems were studied to further explore the epidemiologic utility of hair as a practical monitoring tool. First, a simple mathematical model was constructed to explicitly consider the multiple determinants of a measured hair trace metal level. Second, preanalysis hair wash procedures suggested that detergent, alcohol, and distilled water, but not EDTA, wash rinses were sufficient. Third, hair trace metal levels of As, Cd, copper (7440508) (Cu), Pb, and zinc (7440666) (Zn) were temporally consistent with individuals and over the exposure gradient. Fourth, hair and blood Pb levels correlated well indicating that hair Pb reflects endogenous Pb absorption in addition to any exogenous deposition. Current human environmental Pb exposure is a function of fallout as well as airborne Pb. Increased Pb absorption most probably occurs by both respiratory and gastrointestinal routes. Further epidemiologic studies can no longer neglect dustfall metals when estimating environmental exposure.
Analytical-methods; Metal-poisoning; Heavy-metals; Respiratory-system; NIOSH-Author; Gastrointestinal-system; Environmental-contamination; Trace-substances; Toxic-substances; Epidemiology; Dusts;
7440-38-2; 7440-43-9; 7439-92-1; 7440-50-8; 7440-66-6;
Pulmonary System Disorders
Trace Substance in Environmental Health - V, A Symposium, D. D. Hemphill, Ed., University of Missouri, Columbia, Missouri