The effect of amosite and chrysotile asbestos on the clearance of TiO2 particles from the lung.
Environ Res 1976 Oct; 12(2):250-254
Techniques were developed to assess the effects of air pollutants on the alveolar clearance pattern of inert particles deposited in the lungs of laboratory animals. Amosite (12172735) or chrysotile (12001295) asbestos exposures, relatively short in duration (1-3 hours) and high in concentration (about 10 milligrams per cubic meter) depressed the alveolar clearance of titanium-dioxide (1309633)) particles in rats. This effect was not observed when asbestos air concentrations were reduced to about 10 times the Threshold Limit Value, estimated to be 0.1 milligrams per cubic meter. Extending the postexposure observation period and the number of exposures to 11 or 22 a suppressive effect on titanium-dioxide clearance was seen. How important this late effect is can not be determined at this time. However, the effect of high concentrations of amosite or chrysotile at exposures lasting only a short time should be considered with concern.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-functions; Respiratory-mechanics; Carcinogens; Asbestos-dust; Lung-clearance; Air-contaminants; Lung-dust-burden; Exposure-limits; Time-dose-relationship; Toxicology; Test-methods
Radiation Biology & Biophysics University of Rochester Dept of Radiation Bio & Biophy Rochester, N Y 14620
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University of Rochester, Rochester, New York