Toluene diisocyanate (TDI) pulmonary disease: immunologic and inhalation challenge studies.
Butcher BT; Salvaggio JE; Weill H; Ziskind MM
J Allergy Clin Immunol 1976 Jul; 58(1):89-100
Clinical and serologic effects of toluene-diisocyanate, or TDI (584849), exposure were studied in 112 occupationally exposed plant workers. Sera were obtained before and after commencement of TDI production. All subjects were skin-tested with common inhalant allergens and a TDI-human serum albumin conjugate. Total eosinophil counts, immunoglobulin quantitations, and specific antibody assays were performed. Clinically sensitive individuals were tested by provocative inhalation challenge with from 0.005 ppm to the threshold limit value of 0.02 ppm TDI. No TDI-induced immunologic changes were noted with the exception of 3 individuals who demonstrated small positive wheal-and-erythema reactions to TDI- human serum albumin but not to human serum albumin alone. Inhalation challenge with TDI vapor produced airways obstruction. These responses were of the immediate, delayed, and dual type, and were provoked in some cases with levels as low as 0.005 ppm TDI.
NIOSH-Publication; NIOSH-Contract; Contract-099-73-0070; Cyanates; Isocyanates; Occupational-health; Chemical-workers; Chemical-processing-industry; Industrial-plants; Allergic-reactions; Toxicology; Hypersensitivity; Diagnostic-tests; Test-methods; Exposure-limits; Skin-irritation; Respiratory-system-disorders; Respiratory-function-tests; Immunological-tests
Journal of Allergy and Clinical Immunology