Early indices of cancer risk among uranium miners with reference to modifying factors.
Saccomanno G; Archer VE; Saunders RP; Auerbach O; Klein MG
Ann NY Acad Sci 1976 May; 271(1):377-383
Early indices of cancer risk among uranium (7440611) miners were investigated prospectively since 1957 in a population of uranium miners, via yearly sputum cytology. Autopsies were performed on 120 miners with lung cancer and on 26 miners dying from other causes. The results show that cancer of the lung develops from normal epithelial changes that progress from regular squamous cell metaplasia to progressively more and more atypical stages to eventually develop into squamous-cell carcinoma in situ. The in situ stage sheds large numbers of cells that can often be identified as malignant cells in sputum. This allows early diagnosis, localization, and resection, increasing, it is hoped, survival from bronchogenic carcinoma.
NIOSH-Author; Epidemiology; Cancer-process; Respiratory-system-disorders; Diagnostic-tests; Cytopathology; Cell-proliferation; Histopathology; Radioactive-heavy-metals; Medical-treatment; Prognosis; Latent-period
Annals of the New York Academy of Sciences