Case study 4: Inorganic arsenic - ambient level approach to the control of occupational cancerogenic exposures.
Ann NY Acad Sci 1976 May; 271(1):179-186
From 1948 to 1975, nine out of eleven epidemiological studies show significant excess mortality from respiratory cancer among diverse occupations exposed to various inorganic arsenicals and demonstrate that such exposure is carcinogenic in three different tissues. Two of the studies show concomitant significant excess mortality from lymphatic cancer and one from skin cancer. Two studies reveal a dose response relationship between arsenical exposure and lung cancer. Data do not reveal a definite no effect exposure level and, because of the environmental ubiquity of arsenic, (7440382) it is concluded that the arsenic body burden of workers should not be occupationally increased above that produced by the natural ambient level.
NIOSH-Author; Arsenic-compounds; Heavy-metals; Pulmonary-system-disorders; Exposure-limits; Air-contamination; Toxicology; Carcinogens; Carcinogenicity; Epidemiology
Annals of the New York Academy of Sciences