Toxicology of Lead on Kidney and Other Organs.
NIOSH 1976 Feb:86-96
The pathological effects of lead (7439921) on the kidney are reviewed, and evidence is given showing a possible decrease in the ability of individuals with chronic lead nephropathy to excrete lead and showing the possibilities of the role of alcohol (64175), nutrition and other metabolic factors in altering susceptibility to lead toxicity. The review includes stages of lead nephropathy, and photomicrographs of cytopathology in kidney cells involving mitochondrial changes, nuclear inclusion bodies, effects of EDTA (60004) therapy, vacuoles in the cytoplasm and interstitial fibrosis. The evidence of lower urinary lead excretion in chronic compared with acute lead nephropathy is taken from five ship wreckers. The evidence for increased susceptibility to lead toxicity is taken from a case of lead poisoning symptoms developing in a retired man who had worked near lead smelters after repeated, severe episodes of acute alcoholism and poor nutrition.
NIOSH-Author; NIOSH-Contract; Contract-210-75-0026; Toxic-substances; Heavy-metals; Cell-alteration; Intracellular-alteration; Kidney-disorders; Renal-toxicity; Cytotoxicity; Pathology; Metabolism;
7439-92-1; 64-17-5; 60-00-4;
DHEW (NIOSH) Publication No. 76-134
Health Effects of Occupational Lead and Arsenic Exposure, A Symposium, Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH