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Carcinogenicity of arsenic experimental studies.
Health effects of occupational lead and arsenic exposure, a symposium, Carnow BW, ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-134, 1976 Feb; :272-278
Experimental work on arsenic (7440382) and arsenic compounds covers a wide range of doses, with concentrations as low as 0.0004 ppm of the compound in solution to as high a level as 646 ppm in diet given to rodents. Skin absorption studies (skin painting) with mice also reflect a dose range from a low level of 0.4 percent to a high level of 1.8 percent. All of the studies were essentially negative insofar as neoplastic lesions were concerned. There were a few studies in mice which indicated some tumors, adenocarcinomas of the skin, lung, and lymph nodes, but these studies are difficult to interpret on the basis of inadequacy in the design.
NIOSH-Author; NIOSH-Contract; Contract-210-75-0026; Toxicology; Metal-poisoning; Heavy-metals; Arsenic-poisoning; Percutaneous-absorption; Skin-tests; Skin-penetration; Carcinogenesis; Skin-cancer; Lung-cancer; Lymphatic-cancer; Histopathology
Health effects of occupational lead and arsenic exposure, a symposium.
Page last reviewed: December 4, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division