Carcinogenicity of Arsenic Experimental Studies.
NIOSH 1976 Feb:272-278
Experimental work on arsenic (7440382) and arsenic compounds covers a wide range of doses, with concentrations as low as 0.0004 ppm of the compound in solution to as high a level as 646 ppm in diet given to rodents. Skin absorption studies (skin painting) with mice also reflect a dose range from a low level of 0.4 percent to a high level of 1.8 percent. All of the studies were essentially negative insofar as neoplastic lesions were concerned. There were a few studies in mice which indicated some tumors, adenocarcinomas of the skin, lung, and lymph nodes, but these studies are difficult to interpret on the basis of inadequacy in the design.
NIOSH-Author; NIOSH-Contract; Contract-210-75-0026; Toxicology; Metal-poisoning; Heavy-metals; Arsenic-poisoning; Percutaneous-absorption; Skin-tests; Skin-penetration; Carcinogenesis; Skin-cancer; Lung-cancer; Lymphatic-cancer; Histopathology;
DHEW (NIOSH) Publication No. 76-134
Health Effects of Occupational Lead and Arsenic Exposure, A Symposium, Division of Surveillance, Hazard Evaluation and Field Studies, NIOSH