Compartmental analysis of the metabolism of Ni-63(II) in rats and rabbits.
Onkelinx-C; Becker-J; Sunderman-FW Jr.
Res Commun Chem Pathol Pharmacol 1973 Sep; 6(2):663-676
The kinetics of bivalent nickel (7440020) metabolism was studied in rats and rabbits following a single intravenous injection of radiolabeled nickel-chloride. In both species, nickel was rapidly cleared from plasma or serum during the first two days after the injection, and it disappeared at a much slower rate from three to seven days. Urinary excretion of nickel averaged 78 percent of the administered dose during the first day after the injection in rabbits, and 78 percent of the dose during three days after the injection in rats. Measurements of nickel distribution and excretion in both species suggest that nickel is eliminated by first- order kinetics. A mathematical model is proposed which permits the description of nickel metabolism in quantitative terms. The parameter of the model (compartmental volumes and clearances) are reported for the two species. The two-compartment model was tested and verified by its ability to predict correctly concentrations of nickel in serum or plasma of animals which received continuous infusions or repeated daily injections of nickel-chloride.
NIOSH-Publication; NIOSH-Contract; Contract-099-72-0024; Heavy-metals; Blood-chemistry; Metabolic-processes; Urine-chemistry; Serology
Research Communications in Chemical Pathology and Pharmacology