Attempts to induce sensitization in guinea pigs with nickel complexes.
Samitz-MH; Katz-SA; Scheiner-DM; Lewis-JE
Acta Derm Venereol 1975 Oct; 55(6):475-480
Sensitization in guinea-pigs is achieved with a nickel alanine conjugate but not with nickel-sulfate (7786814), nickel-alanine, other nickel-amino-acid complexes or with a complex of nickel (7440020) with soluble guinea-pig skin extract. Nickel-amino-acid complexes and nickel guinea-pig skin complex are thus considered not to be antigenic in guinea-pigs with the technique used. Hypothesis for the apparent failure to induce sensitization are proposed.
NIOSH-Publication; NIOSH-Grant; Nickel-compounds; Heavy-metals; Alanines; Organo-nickel-compounds; Organo-metallic-compounds; Allergies; Hypersensitivity; Antigens
Medicine, Dermatology Univ of Pennsylvania Hospital Duhring Laboratory Building Philadelphia, PA 19104
University of Pennsylvania, Philadelphia, Pennsylvania