NIOSHTIC-2 Publications Search
The pathogenesis of osteonecrosis.
Dysbarism-related osteonecrosis: proceedings of a symposium on dysbaric osteonecrosis. Beckman EL, Elliott DH, eds. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 75-153, 1974 Jan; :67-81
Necrosis of bone may generate a unique pathologic event - replacement through a process called creeping substitution. The replacement may be quite perfect. When the necrotic process involves the articular cortex, the fate of the associated articular cartilege becomes crucial. If the cartilage is necrotic, it will be replaced imperfectly and degenerative arthritic will result. Whatever the cause of the necrosis, the replacement process is identical, and is influenced by the site of involvement, whether articular or nonarticular, age, the state of the articular cartilage, presence or absence of fracture, presence or absence of union, if there is a fracture, and accessibility of the necrotic areas to fibrovascular invasion.
Bone-disorders; Pathology; X-ray-diagnosis; Connective-tissue-disorders; Necrosis; Diagnostic-techniques; Musculoskeletal-system-disorders; NIOSH-Publication
Beckman EL; Elliott DH
Dysbarism-related osteonecrosis: proceedings of a symposium on dysbaric osteonecrosis
CO; OH; TX
Page last reviewed: November 6, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division