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The Pathogenesis of Osteonecrosis.
Necrosis of bone may generate a unique pathologic event - replacement through a process called creeping substitution. The replacement may be quite perfect. When the necrotic process involves the articular cortex, the fate of the associated articular cartilege becomes crucial. If the cartilage is necrotic, it will be replaced imperfectly and degenerative arthritic will result. Whatever the cause of the necrosis, the replacement process is identical, and is influenced by the site of involvement, whether articular or nonarticular, age, the state of the articular cartilage, presence or absence of fracture, presence or absence of union, if there is a fracture, and accessibility of the necrotic areas to fibrovascular invasion.
Bone-disorders; Pathology; X-ray-diagnosis; Connective-tissue-disorders; Necrosis; Diagnostic-techniques; Musculoskeletal-system-disorders; NIOSH-Publication;
Dysbarism-Related Osteonecrosis, Proceedings of a Symposium on Dysbaric Osteonecrosis, NIOSH, Cincinnati, Ohio
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division