Tissue Distribution of C-14-Labeled Ethylene Dibromide in the Guinea Pig.
NIOSH 1975:8 pages
A study was undertaken to determine the tissue distribution of uniformly radiocarbon-labeled ethylene-dibromide (106934) in guinea pigs following intraperitoneal administration. Organs containing the greatest concentration of radioactivity per unit weight (kidneys, liver, adrenals, pancreas, and spleen) were the same organs in which pathologic changes have been reported by other investigators, indicating a direct correlation between tissue levels and target organ toxicity. The principal route of excretion was via the kidneys, 66 percent of the dose appearing in the urine within 72 hours of administration. Fecal excretion for the 72 hour period was relatively insignificant, representing less than 3 percent of the dose.
Brominated-hydrocarbons; Brominated-ethylenes; Fumigants; Radioactive-tracer-analysis; Toxicology;
NIOSH, Center for Disease Control, Cincinnati, Ohio, 8 pages, 9 references