Further studies on the effect of lung antibodies on the pathogenesis of tuberculosis.
J Lab Clin Med 1975 Nov; 86(5):741-745
A study was made to further clarify the role of lung reactive antibodies in tuberculous infection. Following intravenous infection with viable tubercle bacilli, mice received mouse anti- mouse lung antibodies for three weeks. Control groups consisted of tuberculous mice receiving non-lung antibody containing fluid and uninfected mice. A method was developed for quantitating tuberculous infection in these different groups by expressing the number of lesions produced per unit of cross-sectional surface area of the lung. Passive administration of lung antibodies was found to significantly potentiate the number of tuberculous lesions. It was concluded that the antibody in some way lowered the resistance or the tissue to invasion.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system-disorders; Lung-tuberculosis; Infectious-diseases; Immune-reaction; Test-methods; Host-resistance; Tissue-reactions; Pathogenesis
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
The Journal of Laboratory and Clinical Medicine
West Virginia University, Morgantown, West Virginia