Influence of relative humidity on functional effects of an inhaled SO2-aerosol mixture.
McJilton-CE; Frank-R; Charlson-RJ
Am Rev Respir Dis 1976 Feb; 113(2):163-169
Lightly anesthetized guinea pigs are exposed to 1 part per million of sulfur dioxide and 1 milligram per cubic meter of sodium chloride aerosol, individually and in combination, at low and high relative humidities. Changes in pulmonary mechanical function characterized by an increase in flow resistance and decrease in compliance are seen only when the mixture is administered at high relative humidity. The effect is ascribed to absorption of the highly soluble sulfur dioxide into the droplet before inhalation.
NIOSH-Publication; NIOSH-Grant; Toxic-gases; Inhalation; Respiratory-system-disorders; Particulates; Air-contaminants
Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
American Review of Respiratory Disease
University of Washington, Seattle, Washington