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Long-term inhalation reproductive and teratogenic toxicity evaluation of nitrous oxide plus halothane. Final report.
NIOSH 1975 Nov; :1-21
Report on the long term effects of exposure to nitrous-oxide plus halothane on the reproductive performance of female rats and the developmental processes in their offspring. Exposure of mated female rats to the combinations of nitrous-oxide (10024972) and halothane (151677) results in reduced ovulation and implantation efficiency at the higher level of exposure during the first six days after mating and a slightly retarded development of the fetuses at both levels of exposure. Exposure to 10 parts per million (ppm) of halothane plus 500 ppm of nitrous-oxide can cause toxic effects on reproduction in rats, which should be of concern to humans.
NIOSH-Contract; Contract-099-74-0046; Toxic-gases; Anesthetics; Brominated-hydrocarbons; Halogenated-hydrocarbons; Fluorinated-hydrocarbons; Teratogenicity; Toxicity; Genetic-disorders; Reproductive-system-disorders
Final Contract Report
NTIS Accession No.
National Institute for Occupational Safety and Health
Page last reviewed: December 4, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division