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Maximum expiratory flow-volume studies on monkeys exposed to bituminous coal dust.
Moorman-WJ; Lewis-TR; Wagner-WD
J Appl Physiol 1975 Sep; 39(3):444-448
To assess early ventilatory responses at the 2 milligrams per cubic meter bituminous coal dust standard, 23 cynomolgus monkeys were exposed by inhalation to Pennsylvania and Utah coal dust. Pennsylvania coal was selected from a field having a high prevalence of coal workers' pneumoconiosis while the Utah coal was selected from a low prevalence area. After 24 months of exposure, a pattern of pulmonary impairment consistent with peripheral airway obstruction was demonstrated. Reductions were observed in the forced expiratory volume in 1 second, maximum midexpiratory flow rate, and especially maximum expiratory flow at small lung volumes. Hyperinflation was observed in both coal treatments; however, no specific lung volumes differed significantly from controls. No differences were found between the Pennsylvania and Utah treatments. Design and specifications for a new hydraulically operated plethysmograph-respirator are included.
JAPYAA; NIOSH-Author; Fibrosis; Respiratory-system-disorders; Respiratory-function-tests; Measurement-instrumentation; Airborne-particulates
Issue of Publication
Journal of Applied Physiology
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division