Leukocyte recruitment to airways by cigarette smoke and particle phase in contrast to cytotoxicity of vapor.
Science 1975 Aug; 189(4203):634-627
The immediate effects of airborne exposure to vapor or particle phase of unfiltered whole cigarette smoke is studied in hamsters. Airways of hamster lungs show recruitment of polymorphonuclear leukocytes after breathing fresh cigarette smoke in a miniature chamber. Exposure to particles alone by removal of the vapor phase with charcoal does not change the leukocyte response. However, exposure to cigarette smoke vapor after removal of particles with Cambridge filters does not recruit leukocytes but produces nuclear and cytoplasmic vacuoles, double nuclei, and exfoliation of cells. The main agents responsible for the vapor toxicity are suggested to be nitrogen-dioxide (10102440) and formaldehyde (50000).
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Smoking; Tobacco-constituents; Cytopathology; Cytotoxicity; Aldehydes; Nitrogen-oxides
Medicine University of Missouri N424 Medical Center Columbia, MO 65201
University of Missouri Columbia, Columbia, Missouri