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Influence of dietary factors on the gastrointestinal absorption of lead.
Toxicol Appl Pharmacol 1974 Mar; 27(3):685-691
Mice are given 0.2, 2 and 20 milligrams per kilogram orally of lead- acetate (301042) labeled with lead-210. The mean absorption of lead (7439921) is approximately 5 percent for all doses. The presence of food in the gastrointestinal tract reduced lead absorption when a tracer dose was administered but did not affect absorption after 2 milligrams per kilogram. The chelators nitrilotriacetic-acid and sodium-citrate increased absorption of lead, as did orange juice, a source of citric-acid (77929). Milk and the chelating agents, ethylenediaminetetraacetic-acid (60004) and diethylenetriaminepentaacetic-acid (67436) , did not significantly affect lead absorption. Dietary factors are considered useful in determining acceptable levels of lead in food.
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Heavy-metals; Organo-lead-compounds; Toxic-substances; Toxic-dose; Toxic-tolerance; Dietary-effects; Food-contamination; Gastrointestinal-system; Acetic-acids; Lead-absorption; Lead-poisoning; Toxicity; Chelates; Citrates; EDTA
Public Health University of California 108 Earl Warren Hall Berkeley, Calif 94720
301-04-2; 7439-92-1; 77-92-9; 60-00-4; 67-43-6
Neurotoxic Disorders; Neurotoxic-effects
Toxicology and Applied Pharmacology
University of California Berkeley, Berkeley, California
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division