Nervous system degeneration produced by acrylamide monomer.
Environ Health Perspect 1975 Jun; 11:129-133
Review of the neurotoxic property of acrylamide. One major problem discussed is the protection of factory workers engaged in the manufacture of acrylamide. A sensitive test of neurologic function in these individuals, touch sensation, based on the experimental observation of the exquisite vulnerability of Pecinian corpuscles in acrylamide intoxicated cats, is presently under consideration. The second area for concern is the exposure of the populace to minute amounts of neurotoxic acrylamide monomer which contaminate acrylamide polymers currently deployed in the environment. Federal restrictions on the maximum permitted exposure to acrylamide, based on a largely clincial study of acrylamide neurotoxicity conducted ten years ago, may require a re-evaluation in the light of recent advances which have pinpointed the initial sites of nerve fiber degeneration.
NIOSH-Publication; NIOSH-Grant; Nervous-system-disorders; Toxic-substances; Neurotoxicity; Amides; Plastics
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
Environmental Health Perspectives
Yeshiva University, New York, New York