Byssinosis: airway responses in textile dust exposure.
J Occup Med 1975 Jun; 17(6):357-359
Hemp dust and hemp dust extracts were tested in healthy subjects pretreated with propranolol (318989), ascorbic-acid, and disodium- cromoglycate (DSCG), in order to obtain more information on the mechanism of textile dust effects. The inhalation of textile dusts causes bronchoconstriction. The airway responses to these dusts are potentiated by propranolol and inhibited by an antihistamine and by ascorbic-acid. Administration of disodium-cromoglycate by spinhaler 30 minutes prior to challenge with hemp dust or hemp dust extract protected some subjects against the airway constrictor effect, mostly those with a large acute reduction in flow rates. Textile dust extracts contain a histamine releasing agent, which explains their airway constrictor effect. This agent is a highly water- soluble, heat-stable, low-molecular-weight compound which has not yet been chemically identified. In the prevention and control of byssinosis, the administration of drugs such as ascorbic-acid or disodium-cromoglycate should be considered in addition to engineering methods.
JOCMA7; NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Organic-dusts; Dust-inhalation; Respiratory-system-disorders; Vitamins; Respiratory-functions; Medical-treatment; Control-measures; Preventive-medicine; Antihistamines; Pharmacology
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Journal of Occupational Medicine
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