NIOSHTIC-2 Publications Search

Lung volumes, mechanics, and single-breath diffusing capacity in anesthetized cats.

Authors
Watanabe-S; Frank-R
Source
J Appl Physiol 1975 Jun; 38(6):1148-1152
NIOSHTIC No.
00048135
Abstract
We measured lung weight, lung volumes, pulmonary mechanics, and carbon monoxide transfer (DLCO, single-breath method) in healthy cats (3.3 +/- 0.4 kg) that were anesthetized, paralyzed, and mechanically ventilated through a tracheal cannula. Compared with Stahl's predicted values which were based on regression analyses of data collected from several species, our cats had larger and more compliant lungs in relation to body weight, higher DLCO per unit body weight, and similar DLCO/TLC (size independent constant). Compared with Robinson et al.'s values derived entirely from studies on dogs, our cats had significantly smaller lung volumes and DLCO per unit body weight, DLCO/TLC and similar ratios of CL/FRC. Several factors appear to contribute to the functional variations among mammalian species: differences in the relation of lung to body weight, differences in the relation of chest wall compliance to lung compliance, and differences in the fundamental structure and design of the respiratory systems. Differences in methodology are acknowledged to be an additional factor.
Keywords
NIOSH-Publication; NIOSH-Grant; Biomechanics; Lung-function-tests; Respiratory-system; Physiological-measurements; JAPYAA
Contact
Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
CODEN
JAPHEV
Publication Date
19750601
Document Type
Journal Article
Funding Amount
420211.00
Funding Type
Grant
Fiscal Year
1975
Identifying No.
Grant-Number-R01-OH-00340
Issue of Publication
6
ISSN
8750-7587
Priority Area
Respiratory-system
Source Name
Journal of Applied Physiology
State
WA
Performing Organization
University of Washington, Seattle, Washington
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division