NIOSHTIC-2 Publications Search

Lung volumes, mechanics, and single-breath diffusing capacity in anesthetized cats.

Watanabe S; Frank R

J Appl Physiol 1975 Jun; 38(6):1148-1152

http://jap.physiology.org/cgi/content/abstract/38/6/1148

00048135

We measured lung weight, lung volumes, pulmonary mechanics, and carbon monoxide transfer (DLCO, single-breath method) in healthy cats (3.3 +/- 0.4 kg) that were anesthetized, paralyzed, and mechanically ventilated through a tracheal cannula. Compared with Stahl's predicted values which were based on regression analyses of data collected from several species, our cats had larger and more compliant lungs in relation to body weight, higher DLCO per unit body weight, and similar DLCO/TLC (size independent constant). Compared with Robinson et al.'s values derived entirely from studies on dogs, our cats had significantly smaller lung volumes and DLCO per unit body weight, DLCO/TLC and similar ratios of CL/FRC. Several factors appear to contribute to the functional variations among mammalian species: differences in the relation of lung to body weight, differences in the relation of chest wall compliance to lung compliance, and differences in the fundamental structure and design of the respiratory systems. Differences in methodology are acknowledged to be an additional factor.

NIOSH-Publication; NIOSH-Grant; Biomechanics; Lung-function-tests; Respiratory-system; Physiological-measurements; JAPYAA

Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105

JAPHEV

19750601

Journal Article

420211.00

Grant

1975

Grant-Number-R01-OH-00340

6

8750-7587

Respiratory-system

Journal of Applied Physiology

WA

University of Washington, Seattle, Washington