Block of neuromuscular transmission by methyl mercury.
Barrett-JN; Botz-D; Chang-DB
Behavioral Toxicology: Early Detection of Occupational Hazards. Xintaras C, Johnson BL, De Groot I, eds., Washington, DC: National Institute for Occupational Safety and Health, (NIOSH) 74-126, 1974 Jan; :277-284
Low concentrations of free methyl mercury (1-3 ppm) irreversibly block synaptic transmission in an isolated frog neuromuscular preparation. The time to block decreases with increasing methyl mercury concentration and with increasing temperature. This block of transmission is due to failure of the presynaptic nerve action potential to propagate to the nerve terminals. The spontaneous release of acetylcholine from nerve terminals is greatly accelerated by methyl mercury, suggesting that methyl mercury depolarizes the presynaptic nerve terminals. Higher doses of methyl mercury (10 ppm) significantly reduce the recorded resting potential of muscle fibers.
Alkyl-mercurial; Mercury-poisoning; Metal-poisoning; Organomercury-compounds; Neuromuscular-disorders
Xintaras-C; Johnson-BL; De Groot-I
Behavioral Toxicology: Early Detection of Occupational Hazards
University of Washington