In vivo conversion of methylene chloride to carbon monoxide.
Ratney RS; Wegman DH; Elkins HB
Arch Environ Health 1974 Apr; 28(4):223-226
A group of workers exposed to 180 to 200 ppm of methylene chloride had carboxyhemoglobin levels of about 4.5% as measured by alveolar carbon monoxide concentrations at the beginning of their workday. This rose to about 9% after eight hours of exposure and then dropped exponentially to 4.5% by the time they started working the next day. The 24-hour time-weighted average concentration of carboxyhemoglobin was 7.3% compared with 2.7% for persons exposed to 35 parts per million of carbon monoxide or 3.8% for persons exposed to 50 parts per million of carbon monoxide. On the basis of these observations, it is proposed that the threshold limit value for methylene chloride be reduced to 75 to 100 parts per million to avoid body burdens of carboxyhemoglobin greater than these allowed persons exposed to exogenous carbon monoxide.
NIOSH-Publication; NIOSH-Grant; Plastic-industry; Blood-disorders; Respiratory-gas-analysis; Toxicology; Chlorinated-hydrocarbons; Chlorinated-methanes; Organic-solvents; Exposure-limits; Prevention; Control-measures; Blood-chemistry; Metabolism
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