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Chromium complexes with proteins and mucopolysaccharides and their relationship to chromium allergy in sensitized guinea pigs.
Katz SA; Scheiner DM; Klein AW; Samitz MH
Environ Res 1974 Apr; 7(2):212-219
An experimental study is presented on chromium complexes with proteins and mucopolysaccharides and their relationship to chromium allergy in sensitized guinea pigs. Purified chromium complexes, prepared from chromium (III) and guinea pig serum albumin, guinea pig gamma globulin, heparin, chondroitin sulfate, protein, or mucopolysaccharide, and containing no free chromium were injected intradermally into albino guinea pigs previously sensitized to chromium. The guinea pigs were observed for chromium allergy reactions. The chromium-albumin complex was the only complex studied that produced a significant incidence of allergic reactions indicating albumin as a possible carrier for chromium in the allergic response mechanism.
NIOSH-Publication; NIOSH-Grant; Dermatology; Dermatitis; Immunology; Dialysis; Metals; Sensitization; Hypersensitivity; PM9007834; PM9006535; PM9007287; PM9005496
Medicine, Dermatology Univ of Pennsylvania Hospital Duhring Laboratory Building Philadelphia, PA 19104
Issue of Publication
University of Pennsylvania, Philadelphia, Pennsylvania
Page last reviewed: November 27, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division