Alterations of barbiturate action following 1,1-dichloroethylene, corticosterone, or acrolein.
Arch Int Pharmacodyn Ther 1973 Oct; 205(2):281-292
Alterations of barbiturate action following 1,1-dichlorethylene (75354), corticosterone (50226), or acrolein (107028) were experimentally studied. The compounds were tested for their effects on pentobarbital (76744) or hexobarbital (50099) sleeping time. 1,1- Dichloroethylene prolonged pentobarbital sleeping time between 2 and 4 hours after oral administration. Liver injury as measured by glucose-6-phosphatase depression was not detected at this time, and hexobarbital sleeping time was not affected. Corticosterone also prolonged pentobarbital sleeping time only. Acrolein prolonged both pentobarbital and hexobarbital sleeping time. The mechanism of these effects appeared to differ. 1,1-Dichloroethylene caused an altered absorption or distribution of pentobarbital. Corticosterone pretreatment resulted in an increase in the central nervous system sensitivity to pentobarbital. Acrolein produced ascites and increased hematocrit, which may have altered the absorption or distribution of both barbiturates. The data suggested that the action of pentobarbital was more easily altered by changes in absorption, distribution, or increased central nervous system sensitivity than was the action of hexobarbital.
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Archives Internationales de Pharmacodynamie et de Therapie
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