Synchronization of augmented luteinizing hormone secretion with sleep during puberty.
Boyar-R; Finkelstein-J; Roffwarg-H; Kapen-S; Weitzman-E; Hellman-L
N Engl J Med 1972 Sep; 287(12):582-586
Luteinizing-hormone (9002679) was measured in plasma every 20 minutes for 24 hours in 14 children and adolescents in different stages of sexual maturation and in five adult men. Prepubertal children and adult men showed no consistent significant difference between mean luteinizing-hormone concentrations with subjects asleep and awake. In all pubertal subjects, an increase in luteinizing- hormone secretion was associated with sleep that resulted in significantly higher mean luteinizing-hormone concentrations than with the subject awake. By experimental delay in sleep onset, synchronization of this luteinizing-hormone secretory "program" with actual sleep was clearly demonstrated. The number of luteinizing- hormone secretory episodes during night or day sleep corresponded to the number of sleep cycles of rapid and nonrapid eye movements. This finding of a sleep-associated increase in luteinizing-hormone secretory activity provides a biologic index for the identification of puberty.
NIOSH-Publication; NIOSH-Grant; Grants-other; Endocrine-function; Pituitary-functions; Sex-hormones; Age-factors; Physiological-factors; Physiological-response; Growth; Development
Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
New England Journal of Medicine
Montefiore Hospital and Medical Center, New York, New York