The effect of lung reactive antibodies on the pathogenesis of tuberculosis.
Clin Exp Immunol 1971 Dec; 9(6):809-819
Injections of washed mouse lung-CCT suspended in Freund's complete adjuvant are given to mice and guinea-pigs to stimulate production of homologous and heterologous mouse lung-reactive antibodies harvested as peritoneal ascitic fluid and serum, respectively. Reactivity of the homologous antibody is limited to relatively weak, but lung-specific, focal localization in the alveolar septa of recipient mice as demonstrated by immunofluorescence studies. An index of tuberculous involvement is developed that correlates the enhanced spread of tubercle bacilli with administration of heterologous immune serum and allowed quantitation of the immune response as a function of histopathology. The effect of heterologous immune serum on experimental tuberculosis infection is an alteration in the appearance of and an increase in the number of lesions resembling a miliary spread of the organisms not seen in the controls.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Lung-disorders; Antigens; Respiratory-system-disorders; Infectious-diseases
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
Clinical and Experimental Immunology
West Virginia University, Morgantown, West Virginia