Effect of intrapulmonary water instillation on pulmonary lymph flow and composition.
Am J Physiol 1972 Dec; 223(6):1433-1437
Intrapulmonary instillation of water in anesthetized, closed-chest, artificially ventilated dogs is followed by an increase in right lymphatic duct lymph flow. The increase is proportional to the amount of water instilled. A significant decrease in lymph sodium concentration without a significant change in lymph protein concentration is observed following the instillation of 10 milliliters per kilogram water. Evans blue concentration ratio is found to be 19, with a steady-state value of 10 at 5 hours. Intrapulmonary water instillation produces a striking decrease in lymph/plasma Evans blue ratio. In addition to water transport, lymphatics play a specific role in high molecular weight solute transport.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system; Lymphatic-system; Lymph-plasma-ratio; Pulmonary-lymphatics
Physiology Stanford University Sch of Med Department of Medicine Palo Alto, Calif
American Journal of Physiology
Stanford University, Stanford, California