Effect of depth of inhalation on aerosol persistence during breath holding.
Palmes-ED; Wang-C; Goldring-RM; Altshuler-B
J Appl Physiol 1973 Mar; 34(3):356-360
Human subjects inhale aerosol bolus followed by 200-800 milliliters of clean air to a lung volume slightly below threshold limit concentration, to determine the effect of depth of inhalation on aerosol persistence in the respiratory tract during breath holding. The breath is then held from 0.5 to 20 seconds, after which a forced exhalation is made and aerosol recovery is measured as a function of inhaled volume and of time of breath. The bolus results are then compared with those for complete aerosol inhalations in which persistence is measured in the same way. Results show that depth of inhalation has a greater effect on persistence than would be predicted from some current lung models.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system-disorders; Lung-disorders; Physiological-measurements
Environmental Medicine New York Univ Med Ctr 550 First Avenue New York, N Y 10016
Journal of Applied Physiology
New York University, New York, New York