"Nonspecific" interstitial pulmonary fibrosis: association with asbestos fibers detected by electron microscopy.
Miller-A; Langer-AM; Teirstein-AS; Selikoff-IJ
N Engl J Med 1975 Jan; 292(2):91-93
The case history is described of a 63 year old clerk with ventilatory alterations and evidence of diffuse honeycombing, in whom electron microscopy of a lung biopsy specimen demonstrated the presence of a large number of very small chrysotile (12001295) asbestos fibers. The case reported documents the association of submicroscopical chrysotile fibrils with severe pulmonary fibrosis, in the absence of fibers demonstrable by light microscopy. The asbestos content of the patient's lung was calculated to be a minimum 0.45 grams, an amount consistent with a low level occupational exposure.
Pulmonary-system-disorders; Lung-fibrosis; Respiratory-system-disorders; Asbestos-dust; Fibrogenic-dusts; Particle-size-distribution; Respiratory-functions; Histopathology; Asbestosis; Radiology
Community Medicine Mount Sinai School of Medicine Fifth Avenue and 100 Street New York, N Y 10029
New England Journal of Medicine
Mount Sinai School of Medicine, New York, New York